Each of the modifications or coatings has been developed and included for a specific purpose and will be damaged by crushing. Sugar or film coating — surrounds the tablet normally to make it taste better or easier to swallow. Crushing these types of tablets may make them to taste very unpleasant.
Enteric coating — tablets with an enteric coating should never be crushed. These enteric coatings are placed around a drug to protect the drug from the acid environment, protect the stomach from the drug or deliver the drug to the site of action. If a modified release preparation is damaged then the whole dose can be released too quickly in the body, this will mean you will receive a very high dose and be more likely to experience side effects. Do not crush your tablets or open capsules unless a Pharmacist or Doctor has advised you that it is safe and appropriate to do so.
Strachan I, Greener M. Medication related swallowing difficulties may be more common than we realise. Pharmacy in Practice, December 2. Consensus guideline on the medication management of adults with swallowing difficulties. In: Foord-Kelcey G, editor. Note: package insert indicates potential teratogenic effects; material safety data sheet warns against skin contact; health care workers should take appropriate precautions.
Slow-release Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose. Note: do not give as whole tablet, tablets are meant to be given as oral suspension; see company insert. Mucous membrane irritant; Note: women who are, or may become, pregnant, should not handle crushed or broken tablets l.
Slow-release a Note: do not give via NG tubes; crushing, chewing or dissolving tablets can cause rapid release and absorption of a potentially fatal dose. Slow-release b ; Note: crushing, chewing or dissolving tablets can cause rapid release and absorption of a potentially fatal dose. Film-coated Note: active ingredients are surrounded by wax matrix to prevent healthcare exposure; women who are, or may become, pregnant should not handle crushed or broken tablet.
Empty contents into a spoon for administration. Do not swallow the capsule. Do not chew or crush the contents of the capsule.
Mucous membrane irritant; Note: accidentally opened or damaged capsules require rigorous precautions to avoid inhalation or contact with the skin or mucous membranes i. Slow-release; Note: crushing, chewing, or dissolving capsules can cause rapid release and absorption of a potentially fatal dose. Note: irritant; avoid contact with skin or mucous membranes; avoid contact with crushed or broken tablets.
Add to cart. AcipHex rabeprazole Tablet Slow-release AcipHex Sprinkle rabeprazole Capsule Slow-release; Note: contents are intended to be sprinkled on food or liquid but should not be chewed or crushed. Address correspondence to Rundsarah M. Tahboub, M. Reprints are not available from the authors. The authors indicate that they do not have any conflicts of interest. Sources of funding: none reported. Pantoprazole, Prout and the proton pump.
Hosp Med. J Am Pharm Assoc. Review article: the pharmacology of rabeprazole. Aliment Pharmacol Ther. Prakash A, Faulds D. Reilly JP. Am J Health Syst Pharm. Proton-pump inhibitors for gastric acid-related disease. Cleve Clin J Med. An update of its pharmacological properties and clinical efficacy in the management of acid-related disorders.
Omeprazole Prilosec. Package insert. Wayne, Pa. Retrieved May , from: www. Lansoprazole Prevacid. Deer-field, Ill. Rabeprazole Aciphex. Titusville, N. Pantoprazole Protonix. Philadelphia, Pa. Esomeprazole Nexium. Wilmington, Del. Review article: drug interactions with agents used to treat acid-related diseases.
Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. Spechler SJ. GERD and its complications. Mt Sinai J Med. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal anti-inflammatory drugs. N Engl J Med. Lazzaroni M, Bianchi Porro G.
Non-steroidal anti-inflammatory drug gastropathy: clinical results with H2 antagonists and proton pump inhibitors. Ital J Gastroenterol Hepatol. Pantoprazole Protonix I. Esomeprazole provides improved acid control vs. The Red book. Montvale, N. Proton pump inhibitor relabeling for cancer risk not warranted. FDC Rep. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication.
Interactions between H. Br Med Bull. Helicobacter pylori , proton pump inhibitors and gastroesophageal reflux disease. Yale J Biol Med. Richard W. Sloan, M. Hospital and clinical associate professor in family and community medicine at the Milton S. This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.
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